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CLIA Procalcitonin

Chemiluminescence kit for the detection of procalcitonin in human serum.

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Catalog Number: CL-PCT100
Size: 100 tests
Clinical topic: Sepsis & Inflammation
Diagnostic panel: COVID-19
SIRS, Sepsis, and Severe Viral Infection
CLIA Procalcitonin
  • Sepsis identification and monitoring
  • Asses sepsis patient progress and mortality risk
  • Signal to start and discontinue of antibiotic treatment in LRTI
  • Differential diagnosis of community-acquired bacterial versus viral pneumonia
  • Differential diagnosis of bacterial versus viral meningitis

Rising or elevated procalcitonin (PCT) level is a marker for severe bacterial infections, more specific than most other inflammatory markers (cytokines, interleukins, and acute-phase reactants). Normally, PCT is expressed in thyroid C-cells and its levels in circulation are very low. As a response to bacterial infection, PCT is secreted by many tissues in large quantity and its blood concentration rises rapidly. Only extremely severe noninfectious stimuli may elevate blood PCT concentrations.
Low background levels, fast response to a triggering event (detectable in 2-4, peaks in 12-24 hours), illness severity-related response, and the dependence of sustained PCT elevations on ongoing inflammatory stimuli make PCT a superior bacterial infection marker.

Early Detection of Sepsis
Sepsis is a life-threatening organ dysfunction that results from the body’s response to infection (Sepsis 3 definition 2016). To improve outcomes of patients with sepsis, it requires early detection and prompt clinical interventions. Fast and specific response of PCT to a bacterial infection makes it helpful for an early and accurate decision to initiate, escalate, and de-escalate therapy based on clinical assessment.

Bacterial Infection Identification and Antibiotic Therapy Management
In patients manifesting acute infection symptoms, the levels of procalcitonin clearly distinguish bacterial from viral infections and identify patients needing antibiotic therapy.
In acute respiratory tract infections, such as low respiratory tract infection (LRTI), community-acquired pneumonia (CAP), acute exacerbation of asthma or COPD, the use of procalcitonin is useful to initiate or discontinue antibiotics; this results in lower risks of mortality, lower antibiotic consumption, and lower risk for antibiotic-related side effects.
PCT measurement aids to differentiate between bacterial and viral meningitis and start with antibiotic treatment promptly. It is also used in the diagnosis of renal involvement in pediatric urinary tract infections.

COVID-19
From accumulating data and reports, that appears that elevated PCT levels on admission are associated with increasing COVID-19 severity and it has been addressed as a predictor of survival in patients with COVID-19. It can assist clinicians in formulating a tailored treatment approach and promptly provide intensive care to those who are in greater need. Monitoring of PCT aids to detect a secondary bacterial infection and its progression.

Technical specifications

Technical data
References
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Technical data

Assay time17 min
Assay stability30 days on board stability / In use stability until the expiratoin date at storage temperature 2-8 °C
Sample matrix Serum
Sample volume44 µL
Sample stability7 days at 2-8 °C, 24 months at -20 °C
Concentration range125 - 4000 pg/ml
Assay/kit contentReagent Cartridge with specific reagents for the assay, magnetic particles, calibrators
Complementary productsWash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions
Note

Undiluted samples, optional dilution 20-times.

References

References to CLIA Procalcitonin

  • Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993 Feb 27;341(8844):515-8. doi: 10.1016/0140-6736(93)90277-n. PMID: 8094770; PMCID: PMC7141580.
    See more on PubMed
  • Becker KL, Nylén ES, White JC, Müller B, Snider RH Jr. Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab. 2004 Apr;89(4):1512-25. doi: 10.1210/jc.2002-021444. PMID: 15070906.
    See more on PubMed
  • Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013 May;13(5):426-35. doi: 10.1016/S1473-3099(12)70323-7. Epub 2013 Feb 1. PMID: 23375419.
    See more on PubMed
  • Trásy D, Molnár Z. Procalcitonin - Assisted Antibiotic Strategy in Sepsis. EJIFCC. 2017 May 1;28(2):104-113. PMID: 28757818; PMCID: PMC5460008.
    See more on PubMed
  • Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017 Mar;43(3):304-377. doi: 10.1007/s00134-017-4683-6. Epub 2017 Jan 18. PMID: 28101605.
    See more on PubMed
  • Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. PMID: 26903338; PMCID: PMC4968574.
    See more on PubMed
  • Dugar S, Choudhary C, Duggal A. Sepsis and septic shock: Guideline-based management. Cleve Clin J Med. 2020 Jan;87(1):53-64. doi: 10.3949/ccjm.87a.18143. Epub 2020 Jan 2. PMID: 31990655.
    See more on PubMed
  • Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, Vadas L, Pugin J; Geneva Sepsis Network. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med. 2001 Aug 1;164(3):396-402. doi: 10.1164/ajrccm.164.3.2009052. PMID: 11500339.
    See more on PubMed
  • Müller B, Becker KL, Schächinger H, Rickenbacher PR, Huber PR, Zimmerli W, Ritz R. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med. 2000 Apr;28(4):977-83. doi: 10.1097/00003246-200004000-00011. PMID: 10809269.
    See more on PubMed
  • Crisafulli E, Barbeta E, Ielpo A, Torres A. Management of severe acute exacerbations of COPD: an updated narrative review. Multidiscip Respir Med. 2018 Oct 2;13:36. doi: 10.1186/s40248-018-0149-0. PMID: 30302247; PMCID: PMC6167788.
    See more on PubMed
  • Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, Widmer I, Neidert S, Fricker T, Blum C, Schild U, Regez K, Schoenenberger R, Henzen C, Bregenzer T, Hoess C, Krause M, Bucher HC, Zimmerli W, Mueller B; ProHOSP Study Group. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA. 2009 Sep 9;302(10):1059-66. doi: 10.1001/jama.2009.1297. PMID: 19738090.
    See more on PubMed
  • Viereck V, Gamper M. Re: Kirchin V, Page T, Keegan PE, Atiemo KO, Cody JD, McClinton S, Aluko P. Urethral injection therapy for urinary incontinence in women. Cochrane Database Syst Rev. 2017 Jul 25;7:CD003881. doi: 10.1002/14651858.CD003881.pub4. Neurourol Urodyn. 2018 Sep;37(7):2286-2287. doi: 10.1002/nau.23712. Epub 2018 Aug 28. PMID: 30152530.
    See more on PubMed
  • van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, Leib SL, Mourvillier B, Ostergaard C, Pagliano P, Pfister HW, Read RC, Sipahi OR, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB). ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect. 2016 May;22 Suppl 3:S37-62. doi: 10.1016/j.cmi.2016.01.007. Epub 2016 Apr 7. PMID: 27062097.
    See more on PubMed
  • Chaudhary S, Bhatta NK, Lamsal M, Chaudhari RK, Khanal B. Serum procalcitonin in bacterial & non-bacterial meningitis in children. BMC Pediatr. 2018 Nov 2;18(1):342. doi: 10.1186/s12887-018-1314-5. PMID: 30388962; PMCID: PMC6215352.
    See more on PubMed
  • Sitter T, Schmidt M, Schneider S, Schiffl H. Differential diagnosis of bacterial infection and inflammatory response in kidney diseases using procalcitonin. J Nephrol. 2002 May-Jun;15(3):297-301. PMID: 12113602.
    See more on PubMed
  • Ginsburg AS, Klugman KP. COVID-19 pneumonia and the appropriate use of antibiotics. Lancet Glob Health. 2020 Dec;8(12):e1453-e1454. doi: 10.1016/S2214-109X(20)30444-7. Epub 2020 Nov 11. PMID: 33188730; PMCID: PMC7833845.
    See more on PubMed
  • Xu JB, Xu C, Zhang RB, Wu M, Pan CK, Li XJ, Wang Q, Zeng FF, Zhu S. Associations of procalcitonin, C-reaction protein and neutrophil-to-lymphocyte ratio with mortality in hospitalized COVID-19 patients in China. Sci Rep. 2020 Sep 14;10(1):15058. doi: 10.1038/s41598-020-72164-7. PMID: 32929124; PMCID: PMC7490259.
    See more on PubMed
  • Liu ZM, Li JP, Wang SP, Chen DY, Zeng W, Chen SC, Huang YH, Huang JL, Long W, Li M, Gao RF, Guo L, Wu XH. Association of procalcitonin levels with the progression and prognosis of hospitalized patients with COVID-19. Int J Med Sci. 2020 Sep 9;17(16):2468-2476. doi: 10.7150/ijms.48396. PMID: 33029089; PMCID: PMC7532477.
    See more on PubMed
  • Hu R, Han C, Pei S, Yin M, Chen X. Procalcitonin levels in COVID-19 patients. Int J Antimicrob Agents. 2020 Aug;56(2):106051. doi: 10.1016/j.ijantimicag.2020.106051. Epub 2020 Jun 10. PMID: 32534186; PMCID: PMC7286278.
    See more on PubMed

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