CLIA IL-6
Chemiluminescence kit for the detection of interleukin-6 in human serum.
Coming soon
Chemiluminescence kit for the detection of interleukin-6 in human serum.
| Catalog Number: | CL-IL6100 |
|---|---|
| Size: | 100 tests |
| Clinical topic: | Sepsis & Inflammation |
| Diagnostic panel: |
COVID-19 SIRS, Sepsis, and Severe Viral Infection |
Interleukin 6 (IL-6) is a cytokine that plays important roles in both innate and adaptive immunity. IL-6 is upregulated in patients with infection, sepsis, and septicemia and indicates an ongoing inflammatory response. Elevated IL-6 concentrations appear to correspond with the severity of sepsis. IL-6 upregulation is associated with more localized infections but it is also increased in numerous chronic inflammatory disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease.
However, IL-6 is not diagnostic for any specific disease and IL-6 levels must be interpreted within the clinical context of the patient.
Pediatry
Measuring IL-6 may also be used in neonatology and pediatrics. Elevated levels upon admission to the hospital predict septic shock in children. In children with burns, it predicts septic shock and death. In infants at risk of late neonatal sepsis, IL-6 has is increased up to 48 hours before clinical manifestation of bacterial sepsis.
Sepsis and SIRS
In the sepsis and SIRS onset, IL-6 levels rise rapidly, they indicate illness severity and help in severity (or death) prognosis and risk stratification. Increasing IL-6 concentrations may also be used to predict the development of kidney injury in septic patients. In surgery patients, high levels of IL-6 predict the later development of severe sepsis.
Cytokine storm and COVID-19
Cytokine storm is a life-threatening systemic inflammatory syndrome involving elevated levels of circulating cytokines and immune-cell hyperactivation that can be triggered by infections, such as severe COVID-19 disease. IL-6 is a highly sensitive and early indicator of ongoing immunity reaction of the organism and may aid to quickly identify the development of cytokine storm in COVID-19 patients.
| Assay time | 22 min |
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum |
| Sample volume | 54 µL |
| Measuring range | 5–1000 ng/l |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |
| Note | Undiluted samples, optional dilution 10-times |