CLIA MxA
Chemiluminescence kit for the detection of MxA in human whole blood.
Coming soon
Chemiluminescence kit for the detection of MxA in human whole blood.
| Catalog Number: | CL-MxA050 |
|---|---|
| Size: | 50 tests |
| Clinical topic: | Sepsis & Inflammation |
| Diagnostic panel: |
COVID-19 Respiratory Diseases SIRS, Sepsis, and Severe Viral Infection |
MxA plays a key role in host defense against viral infection by acting directly on viral particles (RNA, DNA) in the cell and is involved in the activation of the endoplasmic reticulum. Elevated blood MxA levels are due to the presence of viruses in the body or increased concentrations of IFN I (IFN-α and IFN-β). Thus, it is a specific marker of viral infection as a counterpart to PCT in bacterial infections.
Measurement of MxA is suitable for the confirmation of respiratory diseases (Rotavirus, rhinovirus, respiratory syncytial virus, parainfluenza and influenza virus, metapneumovirus), but also in connection with COVID-19.
The use of therapeutic IFN-beta is associated with the development of neutralizing antibodies (NAbs). NAbs inactivate IFN-beta in 5-10 % of patients. Determination of MxA levels is recommended to monitor the effectiveness of treatment with Interferon (IFN-α and IFN-β) in patients with multiple sclerosis, Sjögren's syndrome, and in women with HCV planning to become pregnant. The decrease of the MxA levels indicates the need to modify the therapy used.
| Assay time | within 30 min (after lysis) |
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | whole blood and after processing diluted whole blood lysate |
| Sample volume | 30 µL of primary sample |
| Sample stability | min. 24 hours at RT and in the fridge |
| Measuring range | 0.625 - 40 ng/ml, after taking into account the dilution factor = 31.25 - 2000 ng/ml. Dilution factor of primary sample: 50x |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |
| Note | Lysing buffer non included |