Chemiluminescence kit for the determination of IgA antibodies against SARS-CoV-2 virus nucleocapsid protein (COVID-19) in human serum or plasma

Catalog Number: CL-CoNA100
Size: 100 tests
Regulatory status: CE IVD
Clinical topic: COVID-19
Diagnostic panel: COVID-19
Respiratory Diseases
  • Detection of IgA antibodies to Nucleocapsid Protein (NP) of SARS-CoV-2
  • Intended for human serum and plasma
  • Nucleocapsid recombinant antigen (rNP) used

Coronaviruses belong to the family of enveloped RNA viruses. In humans, they cause diverse clinical pictures, from the common cold to severe respiratory syndromes (MERS, SARS, and COVID-19). SARS-CoV-2, the cause of COVID-19, is a respiratory virus discovered in 2019. It is primarily transmitted to an individual through close contact with an infected person, during which infectious droplets spread to the environment. Symptoms of COVID-19 are highly variable, ranging from none to life-threatening illness.

The SARS-CoV-2 virus contains four structural proteins: spike (S), nucleocapsid (N), envelope (E), and membrane (M) protein. Responding to the infection, the human immune system raises specific antibodies, starting with IgA and IgM. The IgG antibodies represent a later matured response. Serological tests play only a supporting role in COVID-19 diagnosis. However, they are effective in assessing the immune response of an individuum or population.

Nucleocapsid protein (NP) encapsulates viral genomic RNA and forms a major component of the viral structure. NP is a highly antigenic epitope, which is highly conserved and does not change when the virus is mutated. In patients who have had COVID-19 infection, the anti-NP antibodies are usually measured at higher levels than antibodies to other SARS-CoV-2 proteins.

Technical specifications

Technical data
Related Products

Technical data

Assay time30 min
Sample matrix Serum, Plasma
Sample volume10 µL
Sample stability7 days at 2-8 °C, 24 months at -20 °C
Concentration range5 - 100 U/ml
Assay/kit contentReagent Cartridge with specific reagents for the assay, magnetic particles, calibrators
Complementary productsWash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions


References to CLIA COVID-19 NP IgA

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