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CLIA Tetanus Toxoid IgG

The chemiluminescence assay is intended for the monitoring of Tetanus Toxoid IgG antibodies in human serum or plasma in the general population.

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Catalog Number: CL-TeTG100
Size: 100 tests
Regulatory status: CE IVD
Clinical topic: Infectious Diseases
Diagnostic panel: Vaccination Monitoring
CLIA Tetanus Toxoid IgG

Tetanus is a disease caused by the toxin produced by Clostridium tetani. The incidence of the disease has been reduced worldwide thanks to improved hygiene conditions and extensive vaccination prophylaxis. However, 400,000 to 800,000 people die from this infection every year. Most of these people live in developing countries. Vaccination-mediated protection decreases with age since tetanus antitoxin levels drop as an individual ages.

Adequate antibody protection is achieved by vaccination in childhood and subsequent booster doses. Protection starts at an anti-tetanus toxoid concentration of 0.1 IU/ml. While the vaccine does not usually cause side effects, measuring antibody titre before the booster dose is recommended. This way, side effects such as local oedema, pain and fever can be prevented. Sometimes, failure of the immune response may occur in patients with normal or high levels of all immunoglobulins and in patients with isolated immunodeficiencies.
Therefore, normal immunoglobulin concentrations do not rule out a deficiency of anti-tetanus antibodies and the response to antigenic stimulation should be tested. If antibody tests are performed a long time after the primary and booster vaccination, abnormalities in the occurrence of cell interactions and the level of determined titres may occur.

Technical specifications

Technical data
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Technical data

Assay time30 min
Sample matrix Serum, Plasma
Sample volume10 µL
Measuring range0,01–5,00 IU/ml
Note

The kits are CE-IVD certified and intended for professional use.

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