CLIA CMV IgM
Chemiluminescence kit for the detection of IgM antibodies to Cytomegalovirus in human serum or plasma
Available
Chemiluminescence kit for the detection of IgM antibodies to Cytomegalovirus in human serum or plasma
| Catalog Number: | CL-CMM100 |
|---|---|
| Size: | 100 tests |
| Regulatory status: | CE IVD |
| Clinical topic: | Infectious Diseases |
| Diagnostic panel: |
Herpes Viruses TORCH |
| Producer: | TestLine Clinical Diagnostics s.r.o. |
Human cytomegalovirus (CMV, Human Herpesvirus 5, HHV 5) is a member of the Herpetoviridae family. In humans, it is mainly transmitted by the respiratory apparatus or urogenital tract. The disease is usually asymptomatic or mild, the latent infection can be reactivated in pregnancy, serious disease, stress, or immunosuppressive treatment. An individuum can be reinfected by a different CMV strain. CMV infection during pregnancy causes developmental defects. The virus is easily transmitted through the placenta during primary infection (in 30-50 % of cases); during the reactivation stage, transplacental transmission occurs in only 1% of cases. CMV infection belongs to the TORCH syndrome.
The most widely used approach in serological diagnostics of CMV infection is the detection of specific IgA, IgM, and IgG antibodies.
Antibodies of IgA class are a sign of an active infection – primary infection as well as reactivation. Production of IgM antibodies usually increases a few weeks after infection or reactivation and then decreases slowly. IgM determination alone cannot discriminate primary infection from reactivation. Specific IgG seroconversion indicates primary infection.
Detection of IgG antibodies to CMV is also used as a standard method for screening blood donors.
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Measuring range | 0.5 - 160 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Anchor® Tips, Stackable Cuvette, KleeYa Trigger Pack, KleeYa Wash buffer |
| Note | The kits are CE-IVD certified and intended for professional use. |