CLIA Uromodulin
Chemiluminescence kit for the determination of Uromodulin in human serum and plasma
Coming soon
Chemiluminescence kit for the determination of Uromodulin in human serum and plasma
| Catalog Number: | CL-UMOD050 |
|---|---|
| Size: | 50 tests |
| Clinical topic: | Renal Diseases |
Uromodulin (Tamm–Horsfall protein) is exclusively produced by the epithelial cells of the ascending limb of the loop of Henle. It is abundantly secreted to the urine, to less extend to the bloodstream. Both urine and serum uromodulin concentrations decrease in correlation with the severity of kidney function impairment. In urine, uromodulin polymerizes. In serum, it exists as a monomeric protein, the quantification is more reproducible and clinically reliable in serum.
Serum uromodulin is a sensitive marker of tubular function. In a clinical setting, it can be used for renal function monitoring and diagnosis of nephropathies such as diabetic nephropathy, pyelonephritis, chronic renal insufficiency, interstitial nephropathy. It is a superior marker of tubular function, which allows prediction and early identification of loss in kidney function and early diagnosis of chronic kidney disease even in the asymptomatic phase.
Low serum uromodulin levels are also associated with kidney disease complications resulting in increased overall mortality hypertension and hyperuricemia, cardiovascular morbidity, and impaired glucose metabolism, and the development of prediabetes and diabetes.
The implementation of uromodulin as an innovative parameter on the automated platform KleeYa® makes it available to the public.
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |