CLIA Uromodulin

Chemiluminescence kit for the determination of Uromodulin in human serum and plasma

Coming soon
Catalog Number: CL-UMOD050
Size: 50 tests
Regulatory status: CE IVD
Clinical topic: Renal Diseases
CLIA Uromodulin
  • A sensitive marker of tubular kidney injury correlating with tubular function
  • Early detection of renal function decrease, before clinical symptoms being manifested
  • Prediction of renal disease progress
  • Assessing kidney disease complications

Uromodulin (Tamm–Horsfall protein) is exclusively produced by the epithelial cells of the ascending limb of the loop of Henle. It is abundantly secreted to the urine, to less extend to the bloodstream. Both urine and serum uromodulin concentrations decrease in correlation with the severity of kidney function impairment. In urine, uromodulin polymerizes. In serum, it exists as a monomeric protein, the quantification is more reproducible and clinically reliable in serum.

Serum uromodulin is a sensitive marker of tubular function. In a clinical setting, it can be used for renal function monitoring and diagnosis of nephropathies such as diabetic nephropathy, pyelonephritis, chronic renal insufficiency, interstitial nephropathy. It is a superior marker of tubular function, which allows prediction and early identification of loss in kidney function and early diagnosis of chronic kidney disease even in the asymptomatic phase.

Low serum uromodulin levels are also associated with kidney disease complications resulting in increased overall mortality hypertension and hyperuricemia, cardiovascular morbidity, and impaired glucose metabolism, and the development of prediabetes and diabetes.

The implementation of uromodulin as an innovative parameter on the automated platform KleeYa® makes it available to the public.

Technical specifications

Technical data
References
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Technical data

Assay stability (on board)30 days
Sample matrix Serum, Plasma
Assay/kit contentReagent Cartridge with specific reagents for the assay, magnetic particles, calibrators
Complementary productsWash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions

References

References to CLIA Uromodulin

  • Kuśnierz-Cabala B, Gala-Błądzińska A, Mazur-Laskowska M, Dumnicka P, Sporek M, Matuszyk A, Gil K, Ceranowicz P, Walocha J, Kucharz J, Pędziwiatr M, Bartuś K, Trąbka R, Kuźniewski M. Serum Uromodulin Levels in Prediction of Acute Kidney Injury in the Early Phase of Acute Pancreatitis. Molecules. 2017 Jun 14;22(6):988. doi: 10.3390/molecules22060988. PMID: 28613246; PMCID: PMC6152627.
    See more on PubMed
  • Leiherer A, Muendlein A, Saely CH, Brandtner EM, Geiger K, Fraunberger P, Drexel H. The value of uromodulin as a new serum marker to predict decline in renal function. J Hypertens. 2018 Jan;36(1):110-118. doi: 10.1097/HJH.0000000000001527. PMID: 28858977.
    See more on PubMed
  • Leiherer A, Muendlein A, Saely CH, Ebner J, Brandtner EM, Fraunberger P, Drexel H. Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients. Int J Cardiol. 2017 Mar 15;231:6-12. doi: 10.1016/j.ijcard.2016.12.183. Epub 2016 Dec 29. PMID: 28089453.
    See more on PubMed
  • Leiherer A, Muendlein A, Saely CH, Kinz E, Brandtner EM, Fraunberger P, Drexel H. Serum uromodulin is associated with impaired glucose metabolism. Medicine (Baltimore). 2017 Feb;96(5):e5798. doi: 10.1097/MD.0000000000005798. PMID: 28151855; PMCID: PMC5293418.
    See more on PubMed
  • Risch L, Lhotta K, Meier D, Medina-Escobar P, Nydegger UE, Risch M. The serum uromodulin level is associated with kidney function. Clin Chem Lab Med. 2014 Dec;52(12):1755-61. doi: 10.1515/cclm-2014-0505. PMID: 24933630.
    See more on PubMed
  • Bostom A, Steubl D, Garimella PS, Franceschini N, Roberts MB, Pasch A, Ix JH, Tuttle KR, Ivanova A, Shireman T, Kim SJ, Gohh R, Weiner DE, Levey AS, Hsu CY, Kusek JW, Eaton CB. Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure. Am J Nephrol. 2018;47(4):275-282. doi: 10.1159/000489095. Epub 2018 Apr 26. PMID: 29698955; PMCID: PMC6754623.
    See more on PubMed
  • Scherberich JE, Gruber R, Nockher WA, Christensen EI, Schmitt H, Herbst V, Block M, Kaden J, Schlumberger W. Serum uromodulin-a marker of kidney function and renal parenchymal integrity. Nephrol Dial Transplant. 2018 Feb 1;33(2):284-295. doi: 10.1093/ndt/gfw422. PMID: 28206617; PMCID: PMC5837243.
    See more on PubMed
  • Steubl D, Block M, Herbst V, Nockher WA, Schlumberger W, Satanovskij R, Angermann S, Hasenau AL, Stecher L, Heemann U, Renders L, Scherberich J. Plasma Uromodulin Correlates With Kidney Function and Identifies Early Stages in Chronic Kidney Disease Patients. Medicine (Baltimore). 2016 Mar;95(10):e3011. doi: 10.1097/MD.0000000000003011. PMID: 26962815; PMCID: PMC4998896.
    See more on PubMed
  • Steubl D, Block M, Herbst V, Schlumberger W, Nockher A, Angermann S, Schmaderer C, Heemann U, Renders L, Scherberich J. Serum uromodulin predicts graft failure in renal transplant recipients. Biomarkers. 2017 Mar;22(2):171-177. doi: 10.1080/1354750X.2016.1252957. Epub 2016 Nov 14. PMID: 27790922.
    See more on PubMed

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