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Chemiluminescence kit for the detection of SS-A/Ro60 antibodies in human serum or plasma.

Catalog Number: CL-Ro6050
Size: 50 tests
Regulatory status: CE IVD
Clinical topic: Immunology & Autoimmune Diseases
Diagnostic panel: Rheumatic Diseases
  • Detection of anti-SS-A/Ro60 antibodies, IgG class
  • Evaluating patients with signs and symptoms of a connective tissue disease and positive test for antinuclear antibodies
  • A positive result for SS-A/Ro60 antibodies indicates connective tissue disease, including Sjögren’s syndrome, systemic lupus erythematodes (SLE), or rheumatoid arthritis
  • Intended for human serum and plasma
  • Highly purified native antigen SS-A/Ro60 (60 kDa) is used

SS-A/Ro antigen is a ribonucleoprotein (RNP) complex localized in nucleus and cytoplasm. It consists of hYRNA (small cytoplasmic RNA) and two protein antigens of 52 kDa and 60 kDa (Ro52 and Ro60).

Autoantibodies against Ro60 a Ro52 are often found together; anti-SS-B/La antibodies may also occure. Presence of the SS-A/Ro autoantibodies is typical for Sjögren’s syndrome (50 – 70%) and systemic lupus erythematodes (40 – 50%), especially for certain clinical subunits (subacute cutaneous lupus, neonatal lupus), and rheumatoid arthritis. Anti-SS-A/Ro antibodies can be detected approximately 3 years before the SLE diagnosis is reached. SS-A/Ro antibodies are also associated with features of extraglandular inflammation in SLE patients including vasculitis, purpura, cytopenias, and adenopathy.

While anti-Ro60 antibodies are primarily specific for systemic lupus erythematodes and Sjögren’s syndrome, anti-Ro52 antibodies was proved to be individually present (without anti-Ro60) in systemic scleroderma (20%) and myositis (35%), especially in anti-Jo-1 positive patients. Anti-Ro52 as well as anti-SS-B/La antibodies significantly raise the risk of congenital atrioventricular block (CAVB) development. They may be also present in autoimmune liver disease.

Antigen Used: Highly purified native antigen SS-A/Ro60 (60 kDa) and recombinant antigen SS-A/Ro52 (52 kDa).

Technical specifications

Technical data
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Technical data

Assay stability30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C
Sample matrix Serum, Plasma
Sample volume10 µL
Measuring range0,5-180 U/ml
Assay/kit contentReagent Cartridge with specific reagents for the assay, magnetic particles, calibrators
Complementary productsWash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions

The kits are CE-IVD certified and intended for professional use.


References to CLIA SS-A/Ro60

  • Schulte-Pelkum J, Fritzler M, Mahler M. Latest update on the Ro/SS-A autoantibody system. Autoimmun Rev. 2009 Jun;8(7):632-7. doi: 10.1016/j.autrev.2009.02.010. Epub 2009 Feb 12. PMID: 19393201.
    See more on PubMed
  • Zampeli E, Mavrommati M, Moutsopoulos HM, Skopouli FN. Anti-Ro52 and/or anti- Ro60 immune reactivity: autoantibody and disease associations. Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):134-141. Epub 2020 Feb 18. PMID: 32083547.
    See more on PubMed
  • Menéndez A, Gómez J, Escanlar E, Caminal-Montero L, Mozo L. Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies: Diagnostic utility of their separate detection. Autoimmunity. 2013 Feb;46(1):32-9. doi: 10.3109/08916934.2012.732131. Epub 2012 Nov 12. PMID: 23039326.
    See more on PubMed
  • Robbins A, Hentzien M, Toquet S, Didier K, Servettaz A, Pham BN, Giusti D. Diagnostic Utility of Separate Anti-Ro60 and Anti-Ro52/TRIM21 Antibody Detection in Autoimmune Diseases. Front Immunol. 2019 Mar 12;10:444. doi: 10.3389/fimmu.2019.00444. PMID: 30915082; PMCID: PMC6423153.
    See more on PubMed


Safety information

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