CLIA ENA screen plus
Chemiluminescence kit for the detection of IgG antibodies to extractable nuclear antigens and centromere B in human serum or plasma.
Available
Chemiluminescence kit for the detection of IgG antibodies to extractable nuclear antigens and centromere B in human serum or plasma.
| Catalog Number: | CL-ENA100 |
|---|---|
| Size: | 100 tests |
| Regulatory status: | CE IVD |
| Clinical topic: | Immunology & Autoimmune Diseases |
| Diagnostic panel: | Rheumatic Diseases |
ENA Screen is a serology test to detect IgG autoantibodies against extractable nuclear antigens (ENAs), which is a subgroup of antinuclear antibodies (ANAs) not reacting with chromatin. ENA screen is usually used following a positive result in an antinuclear antibody (ANA) test.
ENAs are mainly recognized by sera from patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), systemic sclerosis, myositis, Sjögren's, scleroderma, polymyositis, and rheumatoid arthritis. Classical autoantigens detectable in sera from SLE patients are Smith-Protein (Sm), ribonucleoproteins (RNP), Robert-Antigen/Sjögren's A (Ro/SSA), and Lane-Antigen/Sjögren's B (La/SSB); they are usually completed with Scl-70 and Jo-1 antigens. The use of the centromere B antigen is an extension of the standard antigen set.
| Assay time | 30 min |
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Sample volume | 10 µL |
| Sample stability | 7 days at 2-8 °C, 24 months at -20 °C |
| Measuring range | 3 - 320 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |
| Note | The kits are CE-IVD certified and intended for professional use. |