CLIA Adiponectin
Chemiluminescence kit for the detection of adiponectin in human serum.
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Chemiluminescence kit for the detection of adiponectin in human serum.
| Catalog Number: | CL-ADP050 |
|---|---|
| Size: | 50 tests |
| Clinical topic: | Diabetes & Metabolism Disorders |
| Diagnostic panel: | Metabolic Syndrome Panel |
Adiponectin (also referred to as Acrp30) is a protein hormone produced by adipose tissue (adipokine). Adiponectin inhibits glucose synthesis in the liver, increases the tissue response to insulin, and enhances fatty acid oxidation in skeletal muscle. Its levels are positively correlated with many "beneficial" and negatively with "harmful" metabolic markers. Adiponectin acts as a strong protective factor against disorders associated with obesity and especially visceral fat adiposity. It exhibits protective function in the initiation and progression of atherosclerosis. The anti-inflammatory effect of adiponectin may be a major component of its positive effect in the suppression of cardiovascular and metabolic diseases, including atherosclerosis and insulin resistance. Adiponectin also suppresses tumor progression by a mechanism involving its Adipo R1 and Adipo R2 receptors.
The implementation of adiponectin as an innovative parameter on the automated platform KleeYa® makes it available to the public.
Metabolic syndrome and T2DM
Low adiponectin levels indicate an increased risk of metabolic syndrome, insulin resistance, prediabetes, type 2 diabetes mellitus (T2DM), gestational diabetes (GDM), NAFDL, and cardiovascular events, especially atherosclerosis. Adiponectin/leptin ratio is even more sensitive than adiponectin or leptin alone.
Cardiovascular diseases
Adiponectin exhibits antiatherogenic and anti-inflammatory effects and patients with low adiponectin are at an increased risk of CVD like atherosclerosis and coronary artery disease.
Cancer
Low levels of adiponectin indicate an increased risk of some malignancies like breast cancer and prostate carcinomas.
| Assay time | 15 min |
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum |
| Sample volume | 10 µL |
| Sample stability | 7 days at 2-8 °C, 24 months at -20 °C |
| Measuring range | 25 – 800 ng/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |